Senior Research Assistant (all genders) Target ID / CRISPR

☞ Evotec

Aussicht: 127

Update Tag: 19-10-2024

Ort: Hamburg

Kategorie: Kunst / Design Pharma / Chemie / Biotechnologie Apotheker / Pharmavertreter

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Jobinhalt

The Target ID and Validation team within the In Vitro Biology | Early Discoverydepartment in Hamburg is looking for an enthusiastic, creative and passionate:
Senior Research Assistant (all genders)
Target Identification / CRISPR
Full-time and permanent
Your key responsibilities:
  • Develop and optimize cell-based and biochemical assays in 96- and/or 384-well plate format for a wide range of readout technologies to evaluate their effect upon CRISPR-mediated gene manipulation at medium-to-high throughput scale
  • Adapt and miniaturize cell-based assays to high-throughput genetic perturbation screening workflows on robotic liquid handling platforms
  • Establish and optimize cellular assays to assess the effects of genetic perturbations (e.g. CRISPR and RNAi) for target identification/validation using Sanger sequencing, NGS, Western blot/Jess, flow cytometry, immunoassays, high-content imaging, etc.
  • Design, plan, execute, analyze, interpret, and summarize target identification and validation experiments with a wide degree of independence within a team environment, with strong emphasis on CRISPR/Cas technology in disease-relevant models
  • Participate in developing and establishing relevant new technologies, as needed
  • Consistently provide high-quality data on time, document results as requested by project leaders/other stakeholders and record experiments in electronic lab notebooks
  • Write, review, and centrally store relevant SOPs
  • Train and supervise staff in designing and executing broad range of cell-based assays and readout technologies
  • Support scientific project leaders proactively in project execution with high attention to details
Your qualifications:
  • Successfully completed apprenticeship (BTA/CTA/MTA) or bachelor’s/master’s degree in the field of biological sciences with multiple years of professional hands-on experience in an academic, pharmaceutical or biotechnology environment
  • Strong background and hands-on experience in cell culture and genetic manipulation methods (e.g. transfections and infections)
  • Hands-on experience in applying laboratory automation and sample management to genetic perturbation (or compound) screens, as well as optimization and scale-up of cellular assays with phenotypic and/or functional readouts is advantageous
  • Hands-on experience in molecular biology approaches for genotyping of cell lines beneficial
  • Sound understanding and experience in relevant techniques to detect effects of cell manipulation (Western Blotting, Genotyping, Immunofluorescence and/or FACS)
  • Some in vitro pharmacology lab-based research experience in an academic, pharmaceutical or biotechnology environment is an advantage
  • Ability to handle multiple concurrent activities and to work successfully under pressure to tight timelines
  • Self-starter, independent, and flexible team player
  • Excellent communication skills in English
Our offer:
  • A permanent position within a vigorous and exciting professional environment promoted by an open culture and a spirit of community
  • A diverse, international workforce with a dynamic working environment that fosters creativity, innovations and teamwork
  • 30 days of annual holiday, monthly allowance for public transportation, and in-house canteen
  • Capital forming benefits, flexible working hours, holiday pay, and annual bonus depending on performance
To apply, please click on the “Apply” button and provide your application documents (CV and cover letter, including earliest possible start date and salary requirements). We are looking forward to getting to know you and to your application.
FR : Dans le cadre de sa politique Diversité, Evotec étudie, à compétences égales, toutes les candidatures dont celles des personnes en situation de handicap.
ENG : In the frame of our Diversity policy, Evotec considers, with equal competences, all applications including people with disabilities.
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Frist: 03-12-2024

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