PhD Student - Next Generation Biologics Discovery by Microfluidics (m/f/d)

工作内容

The Position

PhD Student - Next Generation Biologics Discovery by Microfluidics (m/f/d)

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

This position is located in the Lead Identification Department within the Large Molecule Research unit, where the discovery and optimization of next generation biotherapeutics is the primary focus. In the Lead Identification department, we employin vivo and in vitro antibody generation technologies in combination with protein engineering, functional high throughput screening and sophisticated in vitro selection technologies. In close collaboration with our therapeutic areas and functions, we convert hypotheses into innovative medicines.

Job mission

We are offering an outstanding opportunity for a PhD student to work within a highly engaged team of antibody engineering and high throughput assay specialists. You will actively participate in establishing a microfluidic based, single-cell screening platform for the selection and characterization of diverse mono- and multispecific antibody formats. In close collaboration with other departments, you will also be involved in the development and implementation of new functional assay readouts, sensitive detection methods and protein engineering approaches.

Your impact

• Implementing a state-of-the-art microfluidic/droplet based screening platform for lead discovery and single cell screening
• Developing and optimizing novel functional assay readouts and sensitive detection methods
• Evolving modular cloning approaches for complex antibody-based format libraries in relevant expression and display host cells
• Devising innovative ways of early functional and biophysical selection and screening of therapeutic lead candidates
  
  

Your profile

You thrive in a dynamic, inclusive environment that gives you full accountability for your own contributions and development. You are dedicated to establishing a culture of mutual support, cross-training, continuous learning and self-organization to meet project and functional goals.

• You hold a Master degree in biology, bioengineering, biophysics or a similar area
• You have excellent analytical, data handling and problem solving skills and a strong passion for science
• You have profound experience in protein interaction assays, flow cytometry and/or cell-based reporter assays
• You have a solid background in protein biochemistry, molecular biology and ideally NGS technologies
• You have ideally already gained experience with microfluidic/droplet based single cell screening and/or hands-on experience with in vitro evolution and display technologies
• You have strong oral and written communication skills in English
  
  

Our commitment

Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.

We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Your contact to us! With people. For people.

Do you need more support?

Our Talent Acquisition Team welcomes your questions. Please send an email to germany.talentaquisition@roche.com.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche at Penzberg, near Munich, employs more than 5,000 people. The site is one of the largest biotechnology centers in Europe and the only Roche site with research, development and production for both Pharmaceuticals and Diagnostics under one roof. From your beginning with Roche, our motivated team will welcome and support you. Numerous opportunities for personal development, flexible work hours, attractive compensation packages and special family assistance programs are available.

Roche is an Equal Opportunity Employer.