PhD Biology, Biotechnolgy - Bioanalytics Liver Injury (m/f/d)- Universitätsklinikum Aachen

☞ Universitätsklinikum Aachen

Aussicht: 191

Update Tag: 18-10-2024

Ort: Aachen North Rhine-Westphalia

Kategorie: Gesundheit / Medizinische Versorgung Teilzeit

Industrie: Medical Practices

Position: Associate

Jobtyp: Part-time

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Jobinhalt

As a transregional provider of secondary to quaternary care, the RWTH Aachen University Hospital combines patient-oriented medicine and nursing, teaching, and research at an international level. With 35 specialist services, across 30 institutes and five interdisciplinary units, the university hospital covers the entire medical spectrum. Our unique setting of a single building hosting health care, research and teaching offering the best conditions for intensive interdisciplinary exchange and close clinical and scientific networking. Around 8,500 employees ensure that holistic patient-oriented management and nursing care is delivered consistently according to recognized quality standards over 45,000 inpatient episodes, through 1400 beds, and 200,000 outpatient attendances per year.The Institute of Clinical Pharmacology - Research project "Prediction of individual phase transition in drug-induced metabolic liver injury" within the framework of the joint research project of the University Hospital Aachen on "Metabolic injury as driver of organ-dependent phase transition" - are seeking aPhD Student (f/m/d).The position starts on 1st January 2023 and is a part-time position (25,03 hours/week/ 65%) funded for the period of 3 years (IZKF funding).As a PhD student, you will work on a collaborative project at the University Hospital Aachen that deals with drug metabolism in patients with liver diseases.
  • Carrying out drug analytics to determine metabolic phenotypes by LC-MS/MS in human biomaterials
  • Establishment of methods for quantitative concentration measurement of specific drug substrates as well as endogenous substrates of relevant enzymes of the cytochrome P450 system
  • Pharmacogenetic studies and evaluations of drug-metabolising enzymes
  • Documentation of medical data and follow-up using databases
  • Completed university studies in biology, biotechnology, biochemistry, analytical chemistry, pharmacy or a comparable degree programme with a bioanalytical focus
  • Practical experience in laboratory work, especially in quantitative LC-MS/MS analysis including method development and sample preparation
  • Good knowledge and experience in the use of databases and software for data processing and analysis (e.g. MS Office programmes, Access, R, SPSS)
  • Good to very good knowledge of English in the biological and medical field (Level C1)
  • Practical experience in LC-MS/MS analysis of (human) biomaterial, especially plasma samples desirable
  • Practical experience in the validation of analytical measurement methods desired
  • Experience in data analysis and handling clinical data
  • Programming skills
  • Interest and joy in scientific work
  • Interest and pleasure in working in an interdisciplinary team
  • Willingness for interprofessional cooperation
  • High ability to work in a team and good work organisation
  • 300 professions under one roof - more variety is not possible.
  • We offer performance-based remuneration in accordance with the provisions of TV-L (EG13), including attractive public service benefits.
  • In addition to a wide range of further education and training opportunities we offer a wide range of health promotion options as well as the extensive university sports program.
  • Monthly employee discounts through our corporate benefits program to save on private shopping.
  • Flexible working hours so that you can better combine work and private life, because your work-life balance is important to us.
  • Attractive conditions for public transport or discounted employee parking so that you have a relaxed commute.
  • A company kindergarten so that your children are always close by
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Frist: 02-12-2024

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