Postdoctoral Scientist (gn)

☞ UKM

看过: 189

更新日: 24-10-2024

位置: Münster North Rhine-Westphalia

类别: R & D IT-软件

行业: Higher Education

水平: Executive

工作类型: Full-time

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工作内容

The bottom-up assembly of tissue from cellular building blocks constitutes a promising, yet highly challenging approach to engineer complex tissues. The challenge lies in controlling cell-cell interactions, which determine how cells organize with respect to each other, how they work together and consequently whether such a multicellular architecture will be functional. We regulate cell-cell interactions with visible light using photoswitchable proteins. These cell-cell interactions provide sustainable, non-invasive, dynamic and reversible control over cell-cell interactions with unprecedented spatial and temporal resolution. We use these photoswitchable cell-cell interactions to assemble cells into multicellular architectures with predictable and programmable organization. The dynamic and reversible nature of the photoswitchable contacts allows us to locally alter interactions at any point in time, to rearrange and obtain asymmetric multicellular structures, which are typical of tissues.

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Finally, we also explore how the photoswitchable cell-cell interactions alter cell behavior and signaling. Ultimately, this will pave the way for the bottom-up assembly of multicellular architectures, enabling us to control precisely and dynamically their organization in space and time as well as regulate how cells work together.

https://www.medizin.uni-muenster.de/physiolchem/research/ag-wegner/

Field of duties
  • Investigation of multicellular architectures
  • Cell based assays (ELISA, Western blot, immunofluorescence, cell culture)
  • Fluorescence microscopy and image analysis
  • Protein and DNA based techniques
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最后期限: 08-12-2024

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