Postdoctoral Researcher (f/m/x) - Protein Homeostasis in Aging and Disease

Faculty of Mathematics and Natural Sciences
Postdoctoral Researcher (f/m/x) - Protein Homeostasis in Aging and Disease
Thorsten Hoppe Laboratory - CECAD Cluster of Excellence in Aging Research

We are one of the largest and oldest universities in Europe and one of the most important employers in our region. Our broad range of subjects, the dynamic development of our main research areas and our central location in Cologne make us attractive for students and researchers from around the world. We offer a wide range of career opportunities in science, technology, and administration.

The Hoppe Lab (www.hoppelab.uni-koeln.de) is looking for a postdoctoral researcher (f/m/x). We address the dynamic regulation of proteolytic pathways that integrate environmental and physiological changes to identify protein degradation networks that protect the proteome of the organism. Our laboratory aims to unravel the interplay between proteolytic networks at the molecular, cellular and organismal levels and to define adaptive mechanisms that ensure proteome integrity in response to environmental stress or disease-associated mutations.

YOUR TASKS

• Studying the conserved regulation of proteostasis networks in C. elegans, mammalian cell culture ,and samples of disease patients
• Combining state-of-the-art (opto)genetics, biochemical and imaging techniques
• Defining proteostasis networks essential for stress resistance and tissue functionality
• The proposed project will have broad implications for the understanding of tissue regeneration and age-associated neurodegeneration. Novel findings may be relevant for future therapeutic interventions against degenerative aging-associated diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s disease.
  

YOUR PROFILE

• Doctorate in Biochemistry or Molecular Biology
• Interested in protein quality control and aging research
• Good communication skills, fluency in English
• Creativity, strong ability for teamwork and problem solving
• Enthusiastic and highly motivated
• Outstanding performance throughout your undergraduate studies and doctorate
  

WE OFFER

• International, enthusiastic and collaborative research group
• A diverse working environment with equal opportunities
• Support in balancing work and family life
• Flexible working time models
• Extensive advanced training opportunities
• Occupational health management offers
  

The University of Cologne is committed to equal opportunities and diversity. Women are especially encouraged to apply and will be considered preferentially in accordance with the Gender Equality Act of the State of North Rhine-Westphalia (Landesgleichstellungsgesetz – LGG NRW). We also expressly welcome applications from people with disabilities / special needs or of equal status.

The position is available as soon as possible on a full-time basis (39,83 hours per week). The position is to be filled for a fixed term of four years. If the applicant meets the relevant wage requirements and personal qualifications, the salary is based on remuneration group 13 TV-L on the pay scale for the German public sector.

HOW TO APPLY

Please send your application (without a photo) with proof of the required qualifications including CV, a letter of intent and names and adresses of at least 2 references by e-mail with the reference number Wiss2306-12to: thorsten.hoppe@uni-koeln.de . The application deadline is 31 July 2023.

For further inquiries, please contact Kerstin Walfort ( office-hoppe@uni-koeln.de ).