Postdoc Biology - Tumor Immunology (m/f/d)- Deutsches Krebsforschungszentrum (DKFZ)

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Vue: 193

Jour de mise à jour: 24-10-2024

Localisation: Dresden Saxony

Catégorie: À temps partiel Science La main doeuvre

Industrie: Research Biotechnology Pharmaceuticals

Niveau: Mid-Senior level

Type d’emploi: Part-time

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le contenu du travail

The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.

The National Center of Tumor Diseases (NCT) Dresden is a joint institution of the German Cancer Research Center, the University Hospital Carl Gustav Carus Dresden, the Faculty of Medicine at TU Dresden, and the Helmholtz-Zentrum Dresden-Rossendorf (HZDR). The NCT with sites in Heidelberg and Dresden is the leading oncological center in Germany and shall be expanded to an international center of excellence regarding point-of-care and individualized cancer medicine.

The German Cancer Research Center is seeking for the partner site Dresden of the National Center of Tumor Diseases a

Postdoc – Tumor Immunology

(Ref-No. 2021-0281) The ability of neoplastic cells to attenuate the immune system and achieve immune resistance is a key feature in tumorigenesis. The project aims at the identification of new strategies for modulating immune resistance in cancer cells and translation of these results into innovative immunotherapies. Specifically the genetic repertoire required for the expression and maintenance of immune checkpoint proteins mediating resistance to T lymphocytes will be studied. A successful candidate will apply methods of reverse genetics such as CRISPR/Cas9-based genome editing and RNA interference in human cancer cells to dissect the function and the regulation of immune checkpoint proteins utilizing loss-of-function screening. Some parts of the open project is based on previous work published in EMBO Reports (Sreevalsan et al., EMBO Reports, 2020, e50155). We are looking for a dedicated and reliable scientist holding a PhD in molecular or cell biology with practical experience in tumor biology and immunology. Candidates with experiences in handling T lymphocytes and performing loss-of-function screens will be preferred. Experience in writing scientific publications and grants is of value. Successful candidates will be working in an international environment and proficiency in written and oral English is required.
  • Interesting, versatile workplace
  • International, attractive working environment
  • Campus with modern state-of-the-art infrastructure
  • Salary according to TV-L including social benefits
  • Possibility to work part-time
  • Flexible working hours
  • Comprehensive further training program
  • Access to the DKFZ International Postdoc Program
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Date limite: 08-12-2024

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